NAD Shot vs IV: Which is Superior for Replenishing Your Vitality?

Mobile IV Therapy

Reviewed by [Sarah Muniz, BSN, RN, Director of Clinical Operations]

Nicotinamide adenine dinucleotide (NAD+) therapies, including NAD shots and NAD IV therapy, are cutting-edge treatments aimed at rejuvenating cellular functions and enhancing overall health. Both methods have their distinct advantages depending on individual health needs and lifestyle preferences. This article will delve into the mechanics, benefits, and considerations of each method, helping you understand what is NAD IV therapy and how it compares to NAD shots.

What is NAD+ and Why is it Important?

NAD+ is a coenzyme essential for numerous biological processes, including energy production, DNA repair, and cell signaling. As we age, NAD+ levels naturally decline, which can lead to cellular dysfunction and various age-related diseases. Supplementing with NAD+ can help mitigate these effects and support better health outcomes.

The Mechanism Behind NAD+ Therapy

NAD+ therapy works by directly increasing the levels of this crucial molecule in your body, which can help counteract the decline and boost cellular metabolism and energy. Whether through NAD IV therapy or shots, the goal is to enhance the body’s intrinsic healing and maintenance capabilities.

NAD Shot vs IV: Comparing the Methods

NAD Shots – Accessibility and Effectiveness

NAD+ shots, accurately referred to as NAD+ SubQ injections, are administered subcutaneously into the back of the arm. This method involves injecting the coenzyme just under the skin, rather than deep into the muscle tissue. Subcutaneous injections allow for a more gradual release and absorption of NAD+ into the bloodstream, making it an efficient way to elevate and maintain NAD+ levels over time.

This administration technique is chosen for its ease and the comfort it offers to the recipient. Injecting into the subcutaneous tissue of the back of the arm minimizes discomfort and simplifies the process compared to intravenous methods, which require more clinical oversight and setup. SubQ injections can be quickly administered and do not require the extended setup and attendance time that IV therapies do, offering a practical solution for individuals looking for a straightforward and minimally invasive option for enhancing their NAD+ levels.

According to a study published in the Journal of Cellular Biochemistry, NAD shots can significantly boost NAD+ levels with a gradual release, supporting sustained cellular benefits.

NAD IV Therapy – Comprehensive and Immediate Benefits

What is NAD IV therapy good for? NAD IV therapy involves the direct infusion of NAD+ into the bloodstream, providing immediate and potent effects. This method is ideal for individuals needing rapid improvements in conditions like chronic fatigue or brain fog. As noted in Clinics in Geriatric Medicine, NAD IV therapy can rapidly elevate NAD+ levels, offering quick therapeutic effects and aiding in everything from energy boost to cognitive enhancement.

Benefits of Each Method

Benefits of NAD Shots (SubQ Injections)

  • Quick administration with no need for an IV setup
  • Ideal for regular maintenance doses
  • Lower cost compared to full IV therapy sessions

Benefits of NAD IV Therapy

  • Immediate absorption and faster results
  • Higher doses possible, suitable for intensive treatment
  • Comprehensive rejuvenation effects noted across various bodily systems

Side Effects and Considerations

While both treatments are generally safe, they can have mild side effects such as discomfort at the injection site for shots and potential vein irritation for IV therapy. It is crucial to consult with healthcare providers to choose the most suitable method based on your health profile and therapeutic goals.

What is NAD IV Therapy Good For? Real-World Applications

NAD IV therapy is particularly effective for severe deficiencies and acute conditions, where rapid delivery can significantly impact recovery and health restoration. On the other hand, NAD shots offer a more gradual approach, suitable for ongoing maintenance and less acute conditions.


Whether choosing a NAD shot or IV, both methods provide valuable pathways to enhance your health by replenishing vital coenzyme levels. The decision should be based on specific health needs, lifestyle, and personal preferences, always under professional medical guidance. When considering NAD+ therapy, the choice between SubQ injections and other forms of administration should align with your specific health objectives, lifestyle requirements, and personal comfort. At PureDropIV, we ensure that every treatment plan is tailored to meet your unique needs, providing professional medical guidance every step of the way. Connect with us today to explore how NAD+ IV or SubQ injections can enhance your health and well-being, conveniently and effectively.

Frequently Asked Questions (FAQs)

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme present in all cells. It plays a critical role in energy production, DNA repair, and cellular communication, essential for maintaining overall health.

Why choose SubQ injections for NAD+?

SubQ injections of NAD+ are administered directly into the fatty tissue beneath the skin, usually at the back of the arm. This method allows for a gradual release and absorption of NAD+ into the bloodstream, providing a sustained boost in coenzyme levels without the need for continuous IV access.

How quickly can I see results from NAD+ SubQ injections?

Results can vary based on individual health conditions and the specific goals of the treatment. Some individuals may notice improvements in energy levels and mental clarity within just a few days, while others might observe more significant benefits over weeks.

Are there any side effects associated with NAD+ SubQ injections?

Most people tolerate NAD+ SubQ injections well. Common side effects are minimal and can include slight discomfort or bruising at the injection site. Rare side effects like mild nausea or headaches typically resolve quickly.

How often should I receive NAD+ SubQ injections?

The frequency of NAD+ SubQ injections can depend on your personal health goals and the advice of your healthcare provider. Typically, a series of injections might be recommended initially, with periodic maintenance doses to sustain desired levels of NAD+.


  1. NIH National Library of Medicine – Nicotinamide Adenine Dinucleotide. Available at:
  2. Harvard Gazette – Scientists pinpoint critical step in DNA repair, cellular aging. Available at:
  3. ScienceDirect – The role of NAD+ in aging: Molecular Mechanisms and Translational Implications. Available at:
  4. Journals of Gerontology – NAD+ in aging: Molecular Mechanisms and Translational Implications. Available at:
  5. Cell Metabolism – Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Available at: